It would be the first time a team has finished a 38-game La Liga season unbeaten and the first in any format since Real avoided defeat in a division of only 10 teams in 1932.
- Lionel Messi has scored 13 goals in his last 13 La Liga games against Villarreal, finding the net in each of his last five at Camp Nou (eight goals). Zinedine Zidane has paid lip-service to the idea of a strong finish in the league, not least to maintain momentum ahead of their season-defining Champions League final against Liverpool in Kiev.
For the 20-year-old, the logic cited behind the temporary switch was based on the Spanish giants allowing him to regain full fitness and his overall confidence back as a key player elsewhere.
And at the end of the first 45 minutes it was Barcelona that walked into the tunnel with a three goal lead.
Valverde has downplayed the importance of his team finishing the campaign as invincibles but after already winning a domestic double, it would represent something of a cherry on top.
Dembele grabbed a deserved goal in the 87th by knocking in from close range after a stunning individual run from substitute Ivan Rakitic.
Adrián Uribe sigue grave, ingresa al quirófano por tercera vez
Esta es la tercera ocasión en tan solo dos semanas que Uribe tiene que ser intervenido quirúrgicamente. Con información de Agencia El Universal .
His run that set up Coutinho's opener in the 11th minute was arguably the moment of the match as he picked up the ball 10 yards inside Villarreal's half before driving past three defenders and unleashing a shot.
Barcelona has scored 94 goals in 36 matches in the league this season.
Dembele takes corners and against Villarreal he beat Denis Cheryshev, once a highly rated youngster with Real Madrid, with a trick after 19 minutes to earn a roar of approval before he was pulled back and fouled.
Sevilla defeated Madrid for its second straight win after enduring a nine-match winless streak in all competitions.
Wissan Ben Yedder opened the scoring for Sevilla, who doubled their lead before the break through Miguel Layun on the stroke of halftime.
Ramos, a former Sevilla player who is often jeered by the crowd when he plays in Seville, missed his first penalty attempt by sending the ball onto the crossbar early in the second half.
"But instead of being grateful, he left the club, staying at home, striking and letting his team-mates down".